Thursday, January 24, 2013

Barry Manilow reschedules Broadway opening night

This image released by Starpix shows Barry Manilow unveiling a street sign reading Manilow Way in Times Square, Tuesday, Jan. 22, 2013 in New York. Manilow is performing in "Manilow on Broadway," until Feb. 23 at the St. James Theatre. (AP Photo/Starpix, Kristina Bumphrey)

This image released by Starpix shows Barry Manilow unveiling a street sign reading Manilow Way in Times Square, Tuesday, Jan. 22, 2013 in New York. Manilow is performing in "Manilow on Broadway," until Feb. 23 at the St. James Theatre. (AP Photo/Starpix, Kristina Bumphrey)

Barry Manilow appears at a press preview for his show "Manilow on Broadway," at the St. James Theatre on Tuesday, Jan. 22, 2013 in New York. (Photo by Dario Cantatore/Invision/AP)

NEW YORK (AP) ? Illness has forced Barry Manilow to postpone the opening night of his latest concert show on Broadway.

Producers said that Thursday's performance of "Manilow on Broadway" ? as well as ones scheduled for Friday and Saturday ? have been rescheduled for late February and early March. Wednesday's show was also canceled.

Producers said in a statement: "It turns out the only thing worse than hell and high water is bronchitis."

The Grammy Award-winning singer of such songs as "Mandy," ''I Write the Songs" and "Looks Like We Made It," will now hold his opening night on Tuesday at the St. James Theatre.

Producers said: "Barry is deeply sorry to disappoint his fans and is doing everything he can to ensure a speedy recovery."

___

Online: http://ManilowOnBroadway.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-01-24-Theater-Barry%20Manilow/id-8a774a4f70504c639ad5404b4d9be027

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Lil Wayne Didn't Trip On Fabolous' NYC Lyrics

'I took what he was saying and tried to put some pride back into New York,' Fab says of recording 'So NY.'
By Nadeska Alexis


Fabolous
Photo: MTV News

Source: http://www.mtv.com/news/articles/1700734/fabolous-lil-wayne-so-ny-track.jhtml

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Wednesday, January 23, 2013

Computers INFORMATION TECHNOLOGY IT 1st Day Cover ...

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Chelsea Handler Kids Ryan Seacrest About Gay Rumors (VIDEO)

Chelsea Handler Kids Ryan Seacrest About Gay Rumors (VIDEO)

Ryan Seacrest and girlfriend Julianne Hough picsRyan Seacrest sat down with Chelsea Handler on Tuesday?s “Chelsea Lately” show, where the talk show host grilled Ryan on his plans to marry Julianne Hough. Handler joked with Seacrest about needing to prove he is not gay by marrying. The interview started off on the Nicki Minaj-Mariah Carey feud, with Ryan saying he thinks ...

Chelsea Handler Kids Ryan Seacrest About Gay Rumors (VIDEO) Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/01/chelsea-handler-kids-ryan-seacrest-about-gay-rumors-video/

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Healing the Brain with Snail Venom

cone snail, conotoxins, pharmacopoeia Image: COURTESY OF STEW ELLINGTON

  • Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...

    Read More??

Conotoxins?the chains of amino acids found in the venom of a cone snail?are medical marvels. In 2003 psychiatrist and environmentalist Eric Chivian of Harvard University described these sea creatures as having ?the largest and most clinically important pharmacopoeia of any genus in nature.? Scientists believe conotoxins could help treat epilepsy, depression and other disorders by interacting with the nervous system.

Why do neuroscientists care about cone snails?

Cone snail venom contains neurotoxins that can target specific locations in the brain and spinal cord. For example, some species of cone snail possess a compound that can act on the same receptors as nicotine. These receptors, located on the surface of neurons, help to govern signaling in the brain.

Neuroscientist J. Michael McIntosh of the University of Utah has found that selectively blocking some of these receptors with a cone snail compound can decrease the use of addictive drugs (so far, just in laboratory animals). Blocking a different subset of those receptors can trigger more consumption of a drug instead. Other compounds have been found to interact with receptors that influence feelings of pain or the growth of tumors.

How dangerous is a cone snail's venom?

The cone snail uses a toxin-filled tooth to harpoon its prey, injecting chemicals that can paralyze, stun or kill an unfortunate fish. Attracted by their colorful shells, divers occasionally collect the snails and make the mistake of stowing them in their swim trunks. The results range from a nasty sting to painful lesions and, in a few cases, death.

Tales of the calamitous cone snail have crept into fiction: the toxin was featured as a murder weapon in the 1970s television show Hawaii 5-O, and in the more recent film Jurassic Park 2 only cone snail venom was powerful enough to fell a Tyrannosaurus rex. Most of the more than 700 species of cone snail, however, are not toxic to humans.

How do people collect these poisonous sea creatures?

The mollusks are typically found in warm and tropical waters, such as in the Caribbean and near the Philippines. ?We can collect snails using a deepwater submersible, scuba diving, deepwater dredging, or simply bending over in the water and picking them up,? says Frank Mari, a biochemist at Florida Atlantic University, one researcher who collects and studies the venom of cone snails.

But the loss of coral reefs and overzealousness of shell collectors have made finding certain species increasingly difficult, which could curtail our access to and understanding of this natural pharmacy. Once researchers have a cone snail, however, they can keep milking it for years in a lab.

How do you milk a cone snail?

Neuroscientist Baldomero Olivera of the University of Utah was faced with this puzzle in the 1980s. One enterprising undergraduate tried inflating a condom and rubbing it against a goldfish. He then set the fish-scented latex into the cone snail's tank. Almost immediately the snail struck, lodging its tooth into the faux fish.

?The sight of an inflated condom floating at the [water's] surface, with a tethered snail swinging like a pendulum below it, was one of those moments that should have been recorded with a camera,? Olivera wrote in the journal Toxicon in 2000.

Today researchers use real fish bait with a latex-topped tube to collect venom. Some scientists now clone genetic material to produce a specific toxin.

What do you do with the venom?

Every cone snail species has easily 1,000 peptides of medical interest, which means cone snails offer millions of research possibilities. Some cone snail toxins show promise as muscle relaxants during surgery and as fast-acting interventions after a stroke or heart attack.


Source: http://rss.sciam.com/click.phdo?i=5a924bceeb9a60b3eb909e9da2000529

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Stocks waver as companies report mixed earnings

Stocks are wavering between small gains and losses as several big U.S. companies report their fourth-quarter financial results.

The Dow Jones industrial average was up four points at 13,654 shortly before noon Tuesday.

The Standard & Poor's 500 index fell two to 1,484. The Nasdaq composite average dropped 10 points to 3,124.

Chemical and bioscience company DuPont reported a sharp drop in income, but the results still beat analysts' forecasts. DuPont's stock rose 1.6 percent.

Johnson & Johnson fell 1 percent after issuing a forecast for 2013 income that fell short of analysts' estimates.

IBM and Google report their results after the closing bell.

The market was closed Monday for the Martin Luther King Jr. holiday.

Source: http://news.yahoo.com/stocks-waver-companies-report-mixed-earnings-165636780--finance.html

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Tuesday, January 22, 2013

Obama stands his ground on fiscal debates

Speaker John Boehner of Ohio listen as President Barack Obama delivers his Inaugural address at the ceremonial swearing-in at the U.S. Capitol during the 57th Presidential Inauguration in Washington, Monday, Jan. 21, 2013. (AP Photo/Carolyn Kaster)

Speaker John Boehner of Ohio listen as President Barack Obama delivers his Inaugural address at the ceremonial swearing-in at the U.S. Capitol during the 57th Presidential Inauguration in Washington, Monday, Jan. 21, 2013. (AP Photo/Carolyn Kaster)

President Barack Obama waves after his speech while Vice President Joe Biden applauds at the ceremonial swearing-in at the U.S. Capitol during the 57th Presidential Inauguration in Washington, Monday, Jan. 21, 2013. (AP Photo/Pablo Martinez Monsivais)

(AP) ? President Barack Obama devoted one word ? "deficit" ? to the issue that brought Washington to the brink of fiscal crises time and again during his first term.

But it was the paragraph that followed in his inaugural address that foreshadowed what's to come ? more hard bargaining and more last-minute deals driven by Obama's own conviction that he now wields an upper hand.

"We must make the hard choices to reduce the cost of health care and the size of our deficit. But we reject the belief that America must choose between caring for the generation that built this country and investing in the generation that will build its future," he said. "The commitments we make to each other ? through Medicare, and Medicaid, and Social Security ? these things do not sap our initiative; they strengthen us. They do not make us a nation of takers; they free us to take the risks that make this country great."

This was the language of his re-election campaign.

And while his speech contained no reference to either political party, his pointed rejection of "a nation of takers" was an implicit reminder of Mitt Romney's infelicitous declaration that Obama's support came from the 47 percent of American voters "who are dependent upon government, who believe that they are victims, who believe the government has a responsibility to care for them, who believe that they are entitled to health care, to food, to housing, to you-name-it."

In keeping with the objective of inaugural addresses, Obama chose to draw attention to the aspirations he hopes will define him rather than the conflicts that have characterized his relations with a divided Congress. He conceded that "outworn programs are inadequate to the needs of our time," but forged ahead with a call for training more math and science teachers, for building roads and even for funding more research labs.

If there was a way to reconcile such spending with demands to stabilize the nation's debt, he didn't mention it.

"Inaugural addresses are intended for the ages, not for a particular moment," said Matt Bennett, a former aide to Al Gore and a vice president of the Democratic-leaning group Third Way. "We will have to wait for the State of the Union, which is addressed directly to Congress, for a clearer sense of what he wants to do in the near-term and how he wants to get it done."

Obama's State of the Union address is scheduled for Feb. 12.

Obama and his aides approached the inaugural speech with a belief that the president had replenished his political strength with his re-election and with his end-of-year deal with Republicans that raised upper-income tax rates on some of the wealthiest Americans.

What's more, Obama delivered the speech as House Republicans were backing off earlier threats to withhold an extension of the nation's borrowing limit if not accompanied by sharp reductions in government spending. Instead, House leaders plan a vote Wednesday to raise the government debt ceiling through May 18 to avert a first-ever default on U.S. obligations.

That retreat, welcomed by the White House, takes the biggest potential crisis off the immediate horizon. But Obama and congressional Republicans still face two other fiscal deadlines: March 1, when steep automatic spending cuts in defense and domestic programs are scheduled to kick in, and March 27, when the current authority to keep government operating runs out. And then, on May 18, another debt limit crisis will loom.

"It's a matter of how you interpret it," said Jared Bernstein, the former chief economist for Vice President Joe Biden. "If you believe the Republicans will make the debt ceiling crisis a quarterly event, then this is a bad outcome. The White House playbook is that there are now enough Republican grownups in the room they can hammer out deals."

House Speaker John Boehner, R-Ohio, set a hopeful tone, declaring that the inaugural was a chance to "renew the old appeal to better angels." Sen. Mitch McConnell of Kentucky, the Senate's Republican leader, referred to the "transcendent challenge of unsustainable federal spending and debt. Republicans are eager to work with the president on achieving this common goal, and we firmly believe that divided government provides the perfect opportunity to do so."

During negotiations last month aimed at avoiding a combination of spending cuts and tax increases, Obama presented Boehner with a proposal that would have reduced spending on Medicare and other entitlement programs by $400 billion; reduced non-entitlement programs by $200 billion over 10 years; and lowered cost-of-living increases for Social Security recipients and other beneficiaries of government programs.

But Obama also wanted some increased spending and still wants more tax revenue through changes in the tax code that would force the rich to pay more, proposals Republicans reject.

Even an ally like Bernstein pointed out that when it comes to spending outside of defense and entitlements, Obama has an incompatible goal of reducing the budget as a share of the economy to the lowest levels since President Dwight Eisenhower's administration.

"It is very hard for me to square those tight budget constraints on the non-defense discretionary side of the budget and many of the aspirations I heard today," Bernstein said. "That said, I think they are exactly the right aspirations."

And there was little about finding common ground in Obama's speech.

"We cannot mistake absolutism for principle, or substitute spectacle for politics, or treat name-calling as reasoned debate," he said.

It was not meant as a self-critique.

___

Follow Jim Kuhnhenn on Twitter: http://twitter.com/jkuhnhenn

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-22-Obama-Fiscal%20Fight/id-844a2e64e4eb4048adc84e3d4735668a

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